Mini-programme on clinical and translational advances in gastroenterology
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- CIVIS focus area
- Open to
- Field of studies
- Medicine and Health
- CIVIS Hub 3
- Course dates
- 14 April 2022 - 26 May 2022
This webinar series on clinical and translational advances in gastroenterology is a teaching offer of the CIVIS partners Sapienza Università di Roma, National and Kapodistrian University of Athens, Universidad Autónoma de Madrid, University of Bucharest, and Université libre de Bruxelles.
Main topics addressed
- Dysbiosis in inflammatory bowel disease: role of the microbiota in the pathophysiology of the disease
- Immune system, microbiota and inflammatory bowel disease
- Gut-liver and gut-brain axis: modulation of gut microbiota
- Cell therapy and stem cells: updates and perspectives
- Decision making in abdominal surgery
- Alcohol-related liver disease and advanced cirrhosis: advances in clinical and translational research
- Chronic intestinal failure: clinical and translational research
- Methodological aspects in the study of the microbiota and inflammatory bowel disease
- Data analysis and statistical approach in microbiota research
- Knowledge of current areas of research in the health domain gastroenterology, hepatology and microbioresearch
- Opportunities to interact and discuss with academics/researchers from CIVIS universities
|Language: English (B2)
Contact hours: 6
Students accepted: 50
*The recognition of ECTS depends on your home university.
This CIVIS course consisting of 7 webinars and 1 workshop will be running for 7 weeks (2 hours each).
A maximum of 50 CIVIS students will be accepted in the course.
This CIVIS course is open to Masters' and PhD students at one of the 10 CIVIS member universities. Applicants should be enrolled in either medicine and surgery (4th - 6th year), biotechnologies, medical biology, microbiology, and PhD students in courses in the relevant areas.
A B2 level of English is required.
Schedule of the course
14 April 2022 - Dysbiosis in inflammatory bowel disease: role of the microbiota in the pathophysiology of the disease
- Presenters: Laila Aldars and Claire Liefferinckx
- Chairs: Javier Gisbert and Daniela De Biase
The microbiota is the wide variety of microorganisms that live in a certain environment. The gut microbiota includes all archaea, bacteria, viruses, and fungi living in the gut. The importance of gut microbiota in human health is now well established. It contributes to many vital functions such as the development of the host immune system, digestion and metabolism, barrier against pathogens or brain-gut communication. Changes in microbial abundances in the gut have been associated with Inflammatory Bowel Disease (IBD). Microbes that are commonly found in high abundance in healthy gut microbiomes, such as F. prausnitzii or R. hominis, are reduced in IBD patients. E. coli, which is usually present in a healthy gut in very low concentrations, is increased in the IBD patients’ gut. In this session, we will describe the changes in the IBD gut microbiota and give some hints about its implication in IBD pathophysiology.
21 April 2022 - Immune system, microbiota and Inflammatory Bowel Disease
- Presenters: Laila Aldars and Claire Liefferinckx
- Chairs: Javier Gisbert and Vincenzo Cardinale
The correct interplay between gut microbiota and the host is essential for human health and, more specifically, for the development of an appropriate immune system. Microbial balance is pivotal for host metabolic and immune functions as well as to prevent disease development. Disturbance in that balance generates dysbiosis making the host susceptible to certain diseases, including Inflammatory Bowel Disease (IBD). The complex interplay between the microbiota, the intestinal mucosa, and the immune system highlights the importance of a holistic approach when unravelling the mechanisms underlying intestinal dysbiosis. In this webinar, we will focus on how microbiota and immune system are developed during life in order to establish immunological tolerance, and present IBD as a paradigm of how defects in this process can lead to disease.
28 April 2022 - Gut-Liver and Gut-Brain axis: modulation of gut microbiota
- Presenters: Vincenzo Cardinale and Daniela De Biase
- Chair: Gratiela Gradisteanu
Despite its containment to surfaces, it is now appreciated that the gut microbiota influences the development and function of all systems of the mammalian body, having both local and systemic effects. Resident microbes can produce molecules that directly impact the development and function of cells within various tissues, contribute energetic-structural and immunitary homeostasis of the intestinal barrier. Enterohepatic circulation represents a vital function of the gut-liver axis. Dysbiosis is associated with ineffective nutrient absorption and a failure to prevent the translocation of luminal bacteria and their products. Gut permeability and bacterial translocation are key pathogenic moments of several diseases, e.g. NAFLD, liver cirrhosis, and the so-called non-communicable preventable chronic diseases. The webinar will deal with the basic knowledge concerning the multidisciplinary background acquired into this topic and will provide recent advances directly connected with the modulation of the gut-liver axis and microbiota for therapeutic purposes. Moreover, we will focus on recently identified metabolites of microbial origin and bacterial components, which have many different effects on host signalling processes. These effects will be discussed in light of their contribution to health vs. disease state.
4 May 2022 - Workshop part 1 - Methodological aspects in the study of the microbiota and Inflammatory Bowel Disease
Presenters: Laila Aldars Garcia and Sebastian Mas-Fontao
Gut microbiome analysis is used to understand many diseases, and preparation, handling, and storage of samples are critical processes that alter the outcomes of downstream DNA-based microbial community analyses. The widespread application of high-throughput genomic approaches has revolutionized the study of complex microbial communities and allowed for the development of sequencing-based approaches. Each methodological stage, from sampling to sequencing, can introduce biases.
Studies in animal models and humans have shown that there is a persistent imbalance in the intestinal microbiome related to IBD, with a substantial body of literature providing evidence for the role of the human gut microbiome on IBD. In general, these studies have several limitations, such as the small sample size, the lack of a valid gold standard (such as endoscopic evaluation) to classify the presence of disease activity, most of them do not take into account previous and current treatments (which can modify the biological state), lack of information about the accuracy of the biomarkers, lack of longitudinal studies, and they find heterogeneous results which have not been validated in independent cohorts. In this session, we will describe the main methodology used in microbiome research including sample collection, sample storage and processing, and sequencing, and provide some ideas for IBD translational microbiome studies.
4 May 2022 - Workshop part 2 - Data analysis and statistical approach in microbiota research
Presenter: Gratiela Gradisteanu
Over the past decade, it has become very clear that the microbiome is an essential player in human health and disease and thus should be analysed to develop innovative treatment strategies. To this end, the field of metagenomics has come a long way in leveraging the advances of next-generation sequencing technologies resulting in the capacity to identify and quantify almost all microorganisms present in human specimens. Nevertheless, the field of metagenomics is still in its infancy, specifically in terms of the limitations in standardization, statistical assessments, computational analysis, and validation due to the vast variability in bioinformatic workflows and experimental design. Our workshop will present the technologies and computational tools used to characterize and study the microbiome. We expect our students to get a flavour of the steps needed to analyze the microbiome as this is an exciting field of research.
5 May 2022 - Cell therapy and stem cells: updates and perspectives
- Presenters: Vincenzo Cardinale and Héctor Guadalajara
- Chair: Lorenzo Ridola
Cell products are the cornerstones of regenerative medicine applications into inflammatory bowel diseases (i.e. fistulizing Crohn Disease) and advanced liver diseases (i.e. end-stage liver disease). Cell therapy refers to the use of living cells in the patient's body implanted in the operation rooms (OR). One of the main modalities is the use of Stem Cells (SCs) - a cell with the unique ability to develop into other specialised cell types in the body, which can serve as a therapy (i.e., cytotherapy) with a medicinal effect. This is the base of regenerative medicine: to restore damaged tissue (restitutio ad integrum) with its architecture and function (i.e. tissue engineering). At present, the efforts are mainly addressed in developing SCs, while advancing in its basic research and therapeutic strategies. In this webinar, we provide an update of these advancements reviewing key concepts such as the biology of SCs and bioengineering, highlighting the main clinic developments with SCs in the field of general surgery and the digestive system. The webinar will also deal with two of the most relevant implications of cell therapy:
- The treatment of complex perianal fistulas in Crohn's disease
- The treatment of liver cirrhosis.
12 May 2022 - Decision making in Abdominal Surgery
- Presenters: Olatz Lopez Fernandez and Héctor Guadalajara
- Chair: Lorenzo Ridola
Shared decision-making (SDM) is related to new ways of approaching patient-centred healthcare when a diagnosis is usually severe, such as colorectal cancer (CRC), and there is more than one option for treatment. It requires physicians and patients to co-work to make quick and joint decisions about the tests and treatments to get through the healing process to guarantee wellness, preserving bioethics principles. This process supports many agents involved: physicians, patients (and families), other clinicians, or new professionals in the healthcare system. At present SDM needs from adapted and tested set of models and aids during, between, and after these encounters which can also involve other health actors and support a humanistic approach of care. In this webinar, we will focus on how SDM can be applied in CRC when deciding about surgery options using new technological patients’ aids to establish a quality join decision and present an SDM paradigm to cover existing gaps in this process to improve patients’ quality of life.
19 May 2022 - Alcohol-related liver disease and advanced cirrhosis: advances in clinical and translational research
- Presenters: Eric Trepo, Stratigoula Sakellariou, Pierre Deltenre and Thierry Gustot
- Chairs: Dina Tiniakos and Christophe Moreno
Alcohol-related liver disease (ALD) is one of the most prevalent types of liver disease worldwide. According to the latest World Health Organisation (WHO) estimates, alcoholic beverage consumption globally resulted in 3 million alcohol-attributable deaths (5.3 % of all deaths worldwide in 2016). ALD comprises a range of disorders including steatosis which can lead to steatohepatitis, fibrosis, cirrhosis, and in some cases hepatocellular carcinoma. Severe alcohol-related steatohepatitis can lead to alcoholic hepatitis (AH), an acute clinical syndrome characterized by the recent onset of jaundice and associated with a poor prognosis. In this webinar, we will review the natural history of ALD, including genetic susceptibility to develop the disease, provide an update on ALD pathology, discuss the management of severe AH and ALD patients developing acute-on-chronic liver failure.
The webinar will develop as follows:
- Natural history of alcohol-related liver disease (Eric Trepo)
- Update on alcohol-related liver disease pathology (Stratigoula Sakellariou)
- Management of severe alcoholic hepatitis (Pierre Deltenre)
- Acute on chronic liver failure and alcohol-related liver disease (Thierry Gustot)
26 May 2022 - Chronic intestinal failure: clinical and translational research
- Presenters: Marianna Arvanitaki and Alia Hadefi
- Chair: Lorenzo Ridola
Chronic intestinal failure is the rarest organ failure, but its prevalence across Europe is increasing. Patients have complex diseases and requirements, and optimal care involves multiple specialities and disciplines. Home parenteral nutrition — the first-line treatment for chronic intestinal failure — is a life-saving therapy.
In this webinar, we will focus on all aspects of chronic intestinal failure including aetiology, classification, complications and management with parenteral nutrition. Lastly, a discussion regarding research opportunities in this field will also be part of this webinar.
The evaluation will be based on students’ CVs and motivation letters. This CIVIS course aims to be diverse. Students from different CIVIS universities will be chosen accordingly (geographical position and gender).
Students should send their CV (including contact details) and motivation letter through the online form before 4 April 2022.
Selected applicants will be notified around 7 April.
- Laila Aldars-Garcia (HULP - Universidad Autónoma de Madrid) – Postdoctoral Researcher. She has a degree in Nutrition, Food Science and Technology from the Universidad Autonoma de Madrid (Spain) and she continued her training in health sciences by taking the Official Master's Degree in Pharmaceutical Sciences at the Universidad Complutense de Madrid (Spain). She completed her doctoral thesis at the University of Lleida (Spain) where she focused on microbiology, as well as on the design of predictive models. During her PhD, she had the opportunity to work at Cranfield University (UK). During her research career she has specialised in microbiology and in recent years she has focused on the study of gut microbiota. Since 2020, Dr Laila Aldars-García has been working in Dr Javier P. Gisbert's group at the Hospital de La Princesa in Madrid investigating the microbiome and metabolome of patients with Inflammatory Bowel Disease using metagenomic and metabolomic approaches.
- Marianna Arvanitaki (Université libre de Bruxelles) - Marianna Arvanitakis finished her medical degree in 1997 in Brussels, Université Libre de Bruxelles, and pursued her fellowship in Internal Medicine/Gastroenterology. She has been working in the Erasme University Hospital since 2002, where she has had the position of Full Professor since 2018. She is head of the Clinic of Pancreatology and Clinical Nutrition. She presented a PhD thesis focused on the diagnosis and treatment of pancreatic diseases in 2007. Her main clinical and research interest are pancreatic diseases, clinical nutrition, and therapeutic endoscopy. She has had an active role in the European Society of Gastrointestinal Endoscopy (ESGE) Governing Board as the individual member representative since 2014 and as the chair of the Education Committee since 2018. She has been part of numerous ESGE guidelines and is on the Editorial Board of the journal Endoscopy. She is also a member of the UEG Scientific Committee since 2014 and chair of the postgraduate teaching (PGT) course. She is also an active member of the European Society of Enteral and Parenteral Nutrition (ESPEN), of the American Gastroenterology Association (AGA) and the American Society of Gastrointestinal Endoscopy (ASGE).
- Vincenzo Cardinale (Sapienza Università di Roma) – Vincenzo Cardinale is an Associate Professor of Gastroenterology at Sapienza Università di Roma. In 2005 he graduated in Medicine and Surgery at Sapienza Università di Roma, under the mentorship of Prof. Domenico Alvaro, who continues to mentor him. He discovered stem/progenitor cell niches in the biliary tree and studied their role in regeneration, liver diseases, diabetes, and malignancies. Following his investigations, biliary research has been revisited. His pioneering studies have been recognized and confirmed in multidisciplinary settings delivering advances in primary sclerosing cholangitis, cholangiocarcinoma, non-anastomotic biliary strictures, and biliary diseases with pancreatic counterparts. His investigations on niches of stem/progenitor cells in the biliary tree, pancreas and duodenum open ground-breaking perspectives in regenerative medicine. Dr Cardinale is currently coordinating a pan-European network to fight cholangiocarcinoma (COST Action CA18122).
- Daniela De Biase (Sapienza Università di Roma) – Associate Professor (Hab. Full Professor). She teaches Biochemistry to students of the Health area: Medicine (including International Medical School, fully taught in English) and Midwifery. She is Erasmus Coordinator of the Faculty of Pharmacy and Medicine (medical area), and a member of CIVIS Health Hub Council and CIVIS WP6 (Task Force Mobility). She is on the teachers’ board of the PhD course in Life Sciences. Her scientific interests are at the crossroad between microbiology, biochemistry and biotechnology. She is an expert on microbial responses to acid stress relying on glutamate/glutamine and leading to GABA production/release. She is moving her research interest also to the study of the human microbiota. Vice-chair of a COST Action CA18113 and Sapienza Coordinator for the recently funded Erasmus Project DOMINOS (for online OSCE). Associate Editor for Frontiers in Microbiology, Microbial Physiology and Metabolism Section.
- Pierre Deltenre (Université libre de Bruxelles) – Pierre Deltenre is Specialist in Hepatology. He completed his medical training at the University of Louvain in Belgium in 1997. He undertook a research fellowship in Professor Valla’s unit at Beaujon Hospital in Clichy in France between 1996 and 1997. Between 1999 and 2013, he was a consultant in CHRU of Lille, France in the team of Professor Mathurin. He achieved his Ph.D. in Erasme Hospital Université libre de Bruxelles, Belgium) in 2012. He worked in Lausanne University Hospital between 2013 and 2017 where he became Assistant Professor. He is now working in the unit of Hepato-Gastroenterology in Clinique Saint-Luc, Namur, and as a consultant in the Department of Hepatology and Gastroenterology of Erasme University Hospital, Brussels, Belgium. Pierre Deltenre is Maître de Conférence at Université libre de Bruxelles, Belgium. He has published more than 120 articles in prominent journals including Gastroenterology, Hepatology, Gut and Journal of Hepatology. His main research interests are complications of cirrhosis and Hepatitis C virus infection.
- Olatz Lopez-Fernandez (FJD - Universidad Autónoma de Madrid) – She is a health psychologist researcher in the University Hospital Fundación Jiménez Díaz, a teaching hospital associated with the Universidad Autónoma de Madrid, Spain. Her expertise is in clinical psychology and applied research developing and managing projects to promote the detection, follow up, and prevention of traditional and emerging health diseases through innovative technologies and methods. She places her work on the educational and healthcare arena from a psychological and humanistic perspective, such as addictions or oncologic problems. She has led projects within the European Commission and the European Parliament and collaborates with many other local and national projects in Spain.
- Javeir P. Gisbert (HULP - Universidad Autónoma de Madrid) – Specialist in Gastroenterology (Senior Consultant), Chief of Section and Director of the Inflammatory Bowel Disease Unit at La Princesa University Hospital, Madrid, Spain. Past-President of the Spanish Inflammatory Bowel Disease Group (GETECCU). Spanish representative/past-President of the European Helicobacter and Microbiota Study Group. Doctor (PhD), Magister in Methodology in Clinical Investigation, and Tenure Professor. Speaker at more than 200 conferences. More than 1000 articles were published in journals. Coordinator/Principal Investigator in more than 250 Research Projects. Member of 15 Medical Societies. Expert reviewer for 28 Scientific Organizations. International Editor of the Cochrane Collaboration. Reviewer for more than 300 scientific journals. Member of the Editorial Board of more than15 journals.
- Gratiela (Pircalabioru) Gradisteanu (University of Bucharest) – Senior Researcher at the Research Institute of University of Bucharest (ICUB), she teaches Medical Microbiology and New targets for developing antimicrobial agents to Master Students at the Faculty of Biology. She is a member of the CIVIS Health Hub Council. Her research interests include microbiome changes in diabetes and metabolic syndrome, in vivo and ex-vivo investigation of host-pathogen crosstalk during the infectious process, oxidative stress in health and disease, assessment of the antimicrobial activity of novel antimicrobial compounds, SARS-CoV-2 diagnostic and omic technologies. She coordinates the microbiome analysis platform at ICUB.
- Héctor Guadalajara (FJD - Universidad Autónoma de Madrid) – He is chairman of Surgery at University Hospital Fundación Jimenez Díaz and Associate Professor at Universidad Autónoma de Madrid since 2014. He is mainly a Colorectal Surgeon participating in 250 procedures per year, with a special dedication to robotic colorectal surgery and proctology. Product of this medical activity he is one of the world pioneers of the stem cell therapy for fistula in Crohn's disease, and provide his expertise to Takeda Company worldwide. Another very important aspect of his career is University teaching and innovation in education. He is one of the main promoters of “Operemos.es”. “Operemos.es” is a contact network that facilitates education to students and people willing to learn technical manoeuvres. As chairman of Surgery, he has been involved in the automatization of the surgical worklist at Quirónsalud, a project that has significantly increased the surgical yields in the Operation Room. And finally, he has been committed to health care humanization implementing sharing decision tools.
- Thierry Gustot (Université libre de Bruxelles) – Thierry Gustot is professor and clinical director of the Liver Transplant Unit at CUB Hôpital Erasme, Brussels, Belgium. He is senior researcher at the Laboratory of Experimental Gastroenterology at Université Libre de Bruxelles and at the Inserm U1149, Centre de Recherche sur l’Inflammation, Paris, France. He is Vice Chairman of the governing board of the EASL-Clif Consortium. He contributed to multiple international collaborative projects (CHANCE, NCT04613921; DECISION H2020, 847949). He is the author and co-author of more than 100 peer-review publications in high-ranked journals (Journal of Hepatology, Gastroenterology, Hepatology, New Engl J Med). He is co-Editor of JHEP Reports and a member of the editorial board of the Journal of Hepatology and Liver Transplantation.
- Alia Hadefi (Université libre de Bruxelles) - Alia Hadefi obtained her medical degree in 2012 at Université libre de Bruxelles (ULB), Belgium and was board-certified gastroenterologist in 2018. She started a PhD in the field of translational research regarding endoscopic bariatric and metabolic therapy (EBMTs) and NAFLD. She is currently working as Fonds Erasme fellow researcher at IRIBHM lab and the laboratory of experimental gastroenterology (ULB). Her main research topics are about EBMTs, NAFLD and nutrition. She is currently working in the department of gastroenterology at Erasme hospital. She is a member of the Young Talent Group and the Young Talent Pool of UEG. Claire Liefferinckx (ULB) – Claire Liefferinckx obtained her medical degree in 2014 at Université libre de Bruxelles. She worked as an FNRS fellow researcher at the laboratory of experimental gastroenterology (ULB) and obtained her PhD thesis in 2019. Her main research topics are about the pharmacokinetics of biologics used in Inflammatory bowel diseases (IBD), the genetics underlying the severity of IBD and the involvement of microbiota in these diseases. She obtained an FNRS post-doctoral fellowship (2019-2022) to investigate the involvement of microbiota in the severity of IBD. In parallel, she works in the department of gastroenterology at Erasme hospital. She is a member of Scicom in the BIRD.
- Sebastián Mas Fontao (FJD - Universidad Autónoma de Madrid) – Principal investigator and group leader of the renal pathology and diabetes laboratory. Degree and PhD in Biochemistry and Molecular Biology (UCM). His field of research focuses on diagnostic, prognostic and therapeutic biomarkers of diabetes complications using -omics approaches (including microbiome analysis) in clinical trials and preclinical models.
- Christophe Moreno (Université libre de Bruxelles) – Christophe Moreno is Professor and Clinical Director of the Liver Unit in the Department of Gastroenterology, Hepatopancreatology and Digestive Oncology in CUB Hôpital Erasme since 2012. He is senior researcher at the Laboratory of Experimental Gastroenterology at Université libre de Bruxelles. He completed his medical training in the Faculty of Medicine of the Université libre de Bruxelles and achieved his PhD in the Laboratory of Experimental Gastroenterology (Université Libre de Bruxelles) in 2007. He was president of the Belgian Association for the study of the Liver (2017-2018), a member of the European Association for the Study of the Liver and the American Association for the Study of Liver disease. He was Associate Editor for the Journal of Hepatology (2014-2019) and is Associate Editor for UEG Journal since 2019. Christophe Moreno has published more than 120 articles in prominent journals including the New England Journal of Medicine, JAMA, Gastroenterology, Hepatology and Journal of Hepatology. His main research interests are alcohol-related liver diseases, complications of cirrhosis, and genetics of liver disease.
- Lorenzo Ridola (Sapienza Università di Roma) – Lorenzo Ridola is Associate Professor in gastroenterology at the Sapienza Università di Roma, Italy. He received his medical education at the Sapienza Università di Roma and graduated in Medicine and Surgery in 2005. In 2009, he specialized in Gastroenterology, at the Sapienza Università di Roma and in 2013, he obtained a PhD in “Clinical and Experimental Hepatology” at the same University. From 2010 Dr. Ridola serves as clinical and research gastroenterologist at Polo Pontino Health hub, Sapienza Università di Roma. Dr Ridola’s scientific interests include the complications of liver cirrhosis and particularly portal hypertension and hepatic encephalopathy. Lorenzo Ridola is a member of the Italian Society of Gastroenterology (S.I.G.E.) and the Italian Association for the Study of the Liver (A.I.S.F.).
- Stratigoula Sakellariou (National and Kapodistrian University of Athens) – Dr Stratigoula Sakellariou is a Histopathologist and Assistant Professor in the 1st Dept. of Pathology, Medical School of National and Kapodistian University of Athens (NKUA). She has a special interest in liver, pancreas and GI tract Pathology. She was a visiting Pathologist at the Institute of Liver Studies, King's College Hospital, London, UK, under the direction of Prof Bernard Portmann. Currently, she is a member of the Liver Transplantation Program of Laiko General Hospital in Athens. Her research is mainly focused on liver diseases. Additionally, she is involved in the study of inflammatory bowel diseases, GI and pancreatic cancer.
- Dina Tiniakos (National and Kapodistrian University of Athens) - Dina Tiniakos is Professor of Pathology and Director, Dept of Pathology, Aretaieion Hospital, National and Kapodistrian University of Athens, Greece, and an academic liver pathologist at the Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, UK. She is the Past President of the European Society of Pathology and Chair, Equality & Diversity Taskforce, United European Gastroenterology. She is an invited member of the International Liver Pathology Group “Gnomes” and the Laennec Liver Pathology Society. Her main research interests are fatty and autoimmune liver disease and hepatocarcinogenesis. She has authored more than 170 peer-reviewed scientific articles and textbooks chapters on liver pathology. She is Associate Editor of “Histopathology” and Editorial Board member of “Journal of Hepatology” and “Annals of Gastroenterology”.
- Eric Trépo (Université libre de Bruxelles) – Dr. Trépo is a Hepatologist and Associate Professor at CUB Hopital Erasme, Université libre de Bruxelles (ULB), Belgium. He is also a Research Associate from the Fund for Scientific Research-FNRS and a steering committee member of the Belgian Association for the Study of the Liver. His research focuses on the susceptibility to alcohol-related liver disease (ALD) especially severe alcoholic hepatitis and hepatocellular carcinoma (HCC). His group aims to further improve our understanding of ALD using genome-wide association studies, and single-cell genomics.