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Webinar: Diabetic cardiomyopathy

8 July 2022

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Format
Online
Open to
CIVIS students & academics
Date
8 July 2022
Apply by
8 July 2022

Sapienza Università di Roma, in collaboration with Universidad Autónoma de Madrid, the University of Bucharest and the NK University of Athens, is organising a webinar on diabetic cardiomyopathy on Friday 8 July 2022 from 15:00 to 19:30 CEST. The event is open to students and academics at CIVIS member universities. 

Clinical and metabolic features of people with diabetes vary considerably, which translates in a heterogeneous risk of diabetes-related complications. In this regard, people with slowly progressive autoimmune diabetes, a type 1 diabetes endotype mimicking type 2 diabetes, have a different risk of microvascular complications and of cardiac autonomic neuropathy, but not of atherosclerotic events, compared to people with type 2 diabetes. This might have significant implications for diabetic heart disease, which results, from a complex interaction between coronary micro and macro-circulation, neuroimmune control and cardiomyopathy. As the pathophysiology and metabolic derangements differ, in-depth knowledge of the differences in heart disease and its risk factors within different diabetes endotypes will significantly contribute to ameliorating the complication risk stratification and will allow personalization of treatment strategies.

This webinar aims to facilitate the knowledge about morpho-functional, biochemical and molecular mechanisms underlying the heterogeneity of diabetic cardiomyopathy, with the final aim of gathering under one roof the European excellence working on this topic. This will provide opportunities for students to be introduced by high-level scientists to a hot topic in cardiovascular disease, and for researchers to create novel collaborations allowing a full description of different diabetic heart phenotypes and their determinants, in relation to the different pathophysiology and metabolic derangements characterizing the heterogeneity of diabetes.

Outline of the scientific program of the webinar

15:00-15:10

 Welcome and Introduction (Giulia D’Amati, Ernesto Maddaloni)

SESSION 1

Molecular mechanisms involved in diabetic cardiomyopathy

Moderators: Ernesto Maddaloni, Iordanis Mourouzis

15:10-15:30

Activation of the mTORC1 and mitochondrial signalling under diabetic and hypertensive cardiomyopathy in patients (Tyanyu Hang)

16:20-16:30

Q&A

15:40-15:55

DPP4 as inducer of endothelial cell senescence and dysfunction: from the adipose tissue to the vascular wall (Ines Valencia)

15:55-16:00

Q&A

SESSION 2

The microbiome, inflammation and type 2 diabetes trialogue

Moderators: Oscar Lorenzo, Giulia D’Amati

16:00-16:20

The gut microbiome involvement in type 2 diabetes and its complications (Gratiela Gradisteanu)

16:20-16:30

Q&A

16:30-16:45

Oral presentation: Evolution of Inflammatory and Oxidative Stress Markers in Romanian Obese Male Patients with Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy - One Year Follow-Up (Laura Petcu)

16:45-16:50

Q&A

16:50-17:10

Virtual coffee break

SESSION 3

The autoimmune diabetic heart

Moderators: Giulia D’Amati, Constantinos Pantos

17:10-17:30

Risk of vascular complications in autoimmune diabetes (Ernesto Maddaloni)

17:30-17:40

Q&A

17:40-17:55

Oral presentation: Cardiac autoimmunity in latent autoimmune diabetes (Rocco Amendolara)

17:55-18:00

Q&A

SESSION 4

Novel therapeutic approaches in diabetic heart failure with and without coronary disease

Moderators: Oscar Lorenzo, Gratiela Gradisteanu

18:00-18:20

Thyroid hormone as a novel therapeutic treatment for diabetes-related heart failure (Iordanis Mourouzis)

18:20-18:30

Q&A

18:30-18:45

Triiodothyronine treatment in a rat model of diabetic cardiomyopathy (Polyxenis Mantzouratou)

18:45-18:50

Q&A

18:50-19:00

Closing remarks (Ernesto Maddaloni, Giulia D’Amati)

Registration

This webinar is open to students, researchers and academics at CIVIS member universities. 

It will be running on Google Meet from 15:00-19:30 CEST on Friday 8 July 2022.

Click here to join the webinar via Google Meet

 

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